When it comes to Osprey Travel Packs, all other travel packs get on their knees and bow down to the ground saying, "we are not worthy, we are not worthy". These packs are the shiz when it comes to a little bag with a lot o' room.
Osprey carries a number of travel packs that optimize space while maintaining those oh-so-wonderful size and weight requirements made by most airlines and other transportation systems. For instance, the Porter 46 is perfect for that "backpacking through Europe to find myself" trip. No little wheelies or handles that dig into your back. Just a comfy fit and a ton of space for all your stuff.
If you are in need of a bag with wheels, the Shuttle 32 Travel Pack is a fantastic option as well as the Slipstream Wheeled Travel Duffel. Both are freakishly durable and are great for that quick business trip or spontaneous weekend vacation. Wish I was cool enough to do that. The vacation not the business trip.